Depends if your daily driver is something you want to have fun with. My V6 is my Daily Driver, heck, it's my only car at the moment. I tuned it. I tuned it when I only have CAI and a Catback Exhaust.
There are both pros and Cons. The engine tune really finetweaks your changed AFR. Freeing up a bit of your handicapped power. Keep in mind, I don't mean from your engine... it's leasing power from your bolt-ons, okay?
Secondly, you have automatic? The tranny tune is well worth it. I have asked Trifecta to give me firmer shifts on Sport mode and Tapshift Manual. While I have torque management deleted, 30% on S, and 10% on D.
This really does take the cake... the car pulls alot faster now. No more sloppy, heavy off the line speeds. Though, it may shorten the life of the Transmission itself... I've heard GM has developed a pretty beefy automatic tranny system.
You can read more about the tune, and my thoughts here:
http://spadesv6.blogspot.com/2011/03...ne-for-v6.html
It's definately something I DON'T regret =D