I'm guessing mainly longer stroke is unfriendly, especially because of the compromises you have to make with the pistons on such builds.
Also, as you say, the extra volume would require a bigger blower, which makes it difficult for the guys going the upgrade route. For me, going from a D1 to an F1(n) would require all new pipes (bigger diameter), etc.
E.g. in my build, if I went forged but stock CID, I would be pushing close to 15lbs through my D1SC and making over 800rwhp - through stock heads, stock intake manifold, stock TB, and shorty headers!
Why do I need to go bigger again?
Now, if I started from scratch, 427 with an F1X and all supporting mods would be the way to go, but right now I don't need a freight train.
Padre