Theres a lot you can do,As I have done with all my trucks,including my current '07 VMAX.
A CAI for one,Then a cat-back exhaust such as a CORSA,a set of LT's help as well,but more importantly...get ahold of this guy here.....
http://blackbearperformance.com/
Justin has tuned numerous late model GM trucks,Its unbelievable what he can do,he can really wake up the 5.3,and change the shift points of the otherwise "busy shifting" 6-spd. tranny,he'll also take out the throttle delay and torque management that hold these trucks back,way back!
He can also disable the AFM and turn off the speed limiter as well.
If you want to read more about him,and what all he can do,look here....
http://www.gm-trucks.com/forums/index.php?showforum=141
He will be the only one who tunes my SS this Spring